Neoadjuvant chemotherapy (NACT) |
an increasingly used approach for treatment of breast cancer |
Circulating Exosomal microRNAs(miRNA) |
small RNA molecules circulating in bodily fluids, potentially serving as biomarkers for treatment response after NACT |
Pathological Complete Response (pCR) |
absence of active cancer cells in a tissue from the tumor site after NACT |
Non-Pathological Complete Response (non-pCR) |
presence of active cancer cells in a tissue from the tumor site after the treatment |
Todorova, Valentina K., et al. “Circulating exosomal microRNAs as predictive biomarkers of neoadjuvant chemotherapy response in breast cancer.” Current Oncology 29.2 (2022): 613-630.
The purpose of the study: to investigate whether circulating exosomal microRNAs could predict pCR in breast cancer patients treated with NACT
20 breast cancer patients
plasma samples -> NACT -> plasma samples
6 patients - pCR
14 patients - non pCR